{"id":1894,"date":"2014-03-04T16:17:54","date_gmt":"2014-03-04T16:17:54","guid":{"rendered":"https:\/\/jacksangelsfoundation.com\/?p=1894"},"modified":"2014-10-07T16:21:37","modified_gmt":"2014-10-07T16:21:37","slug":"important-statistics","status":"publish","type":"post","link":"https:\/\/jacksangelsfoundation.com\/?p=1894","title":{"rendered":"Important Statistics"},"content":{"rendered":"<header class=\"entry-header\">\n<address class=\"entry-title\">Posted on <a title=\"6:24 pm\" href=\"http:\/\/testjack5.wordpress.com\/2014\/03\/04\/important-statistics\/\" rel=\"bookmark\"><time class=\"entry-date\" datetime=\"2014-03-04T18:24:08+00:00\">March 4, 2014<\/time><\/a><span class=\"byline\"> by <span class=\"author vcard\"><a class=\"url fn n\" title=\"View all posts by sandrabeck\" href=\"http:\/\/testjack5.wordpress.com\/author\/sandrabeck\/\" rel=\"author\">sandrabeck<\/a><\/span><\/span><\/address>\n<\/header>\n<div class=\"entry-content\">\n<p>Dear Friends,<\/p>\n<p>Rebekah Sizemore\u2019s son Naithan recently lost his Earthly life to DIPG, Diffuse Intrinsic Pontine Glioma, which is one of the deadliest pediatric cancers with virtually no survivors. \u00a0In tribute to Naithan in his birthday month, she is researching statistics for pediatric cancer, and is sharing her findings with her subscribers on <span class=\"skimlinks-unlinked\">CaringBridge.org<\/span> and is allowing us at Jack\u2019s Angels to share this information as well.<\/p>\n<p>Her contribution is vitally important; we as a society cannot hear of these statistics too many times, until changes are made by our representatives in legislation. \u00a0Awareness is crucial to change. \u00a0Thank you for supporting Rebekah and Jack\u2019s Angels in your willingness to be aware of these facts that are daily companions, if not hourly, to many of us:<\/p>\n<h2>The numbers are abhorrent<\/h2>\n<div id=\"attachment_1897\" style=\"width: 160px\" class=\"wp-caption alignright\"><a href=\"https:\/\/jacksangelsfoundation.com\/wp-content\/uploads\/2014\/03\/Nate.jpg\"><img loading=\"lazy\" decoding=\"async\" aria-describedby=\"caption-attachment-1897\" class=\"wp-image-1897 size-thumbnail\" src=\"https:\/\/jacksangelsfoundation.com\/wp-content\/uploads\/2014\/03\/Nate-150x150.jpg\" alt=\"Nate\" width=\"150\" height=\"150\" srcset=\"https:\/\/jacksangelsfoundation.com\/wp-content\/uploads\/2014\/03\/Nate-150x150.jpg 150w, https:\/\/jacksangelsfoundation.com\/wp-content\/uploads\/2014\/03\/Nate-300x300.jpg 300w, https:\/\/jacksangelsfoundation.com\/wp-content\/uploads\/2014\/03\/Nate.jpg 500w\" sizes=\"auto, (max-width: 150px) 100vw, 150px\" \/><\/a><p id=\"caption-attachment-1897\" class=\"wp-caption-text\">in loving memory of Naithan Sizemore<\/p><\/div>\n<p>&nbsp;<\/p>\n<p>By Rebekah Sizemore \u00a03.4.2014<\/p>\n<div>\n<div><\/div>\n<div>This information is taken directly from The American Childhood Cancer Organization. There is no way to \u201csugar-coat\u201d it and in no way should it be shortened or paraphrased. Cancer is killing our children. We can help\u2026it just depends on whether we are willing to.<\/div>\n<div>\n<div>As of 2012, the population of the United States was 313.9 million. If each person gave ONE dollar per year towards research\u2026that would be more money than what the NIH\/NCI allocated for pediatric cancer this year! One dollar, only one\u2026how much money do we spend on a Starbucks coffee? or a McDonald\u2019s cheeseburger? each and every month. Think about it, let that sink in.<\/p>\n<ul>\n<li><strong><em>Why Research is Needed<\/em><\/strong><\/li>\n<\/ul>\n<\/div>\n<div>\n<div>\n<div>\u00a0<strong><em>Cancer knows no boundaries and as such affects children throughout the world. It is estimated that about 160,000 children world-wide are diagnosed with cancer each year, and approximately 90,000 will eventually die from their illness.1\u00a0\u00a0The exact number of new cases is not known because the number of children with cancer is not registered in many countries.<\/em><\/strong><\/div>\n<div>\n<p><strong><em>In developed countries like the\u00a0United States\u00a0,\u00a0Canada\u00a0, Western European countries,\u00a0Japan\u00a0and\u00a0Australia\u00a0, cancer remains the most common disease killer of children. In developing countries, more than one in two children diagnosed with cancer are likely to die.2\u00a0This is because cancer is detected late and only a small proportion of children have access to the comprehensive cancer treatments currently available in the developed world. Childhood cancer is becoming a more important health issue for these countries and the world community as infectious diseases and diarrhea become increasingly eliminated.<\/em><\/strong><\/p>\n<p><strong><em>In the U.S. and other developed countries, the 1970s-80s brought the advent of chemotherapy \u2018cocktails\u2019 applied to childhood cancer, where toxic compounds that preferentially killed the tumor cells kept many children from death. In spite of tens of millions of public dollars being allocated towards clinical trial research in the\u00a0U.S.\u00a0in the past decade, there has been no change in survivorship of childhood cancer in the past 10 years.2\u00a0\u00a0From 1975 to 1998 the annual death rate from childhood cancer in the\u00a0U.S.\u00a0declined at a rate of 2.7% per year. Despite very aggressive therapies that approach the limits of tolerability for the child, the overall survival rate for\u00a0childhood cancer has remained unchanged since 1998. One in four children who are diagnosed with cancer in the U.S. will die within five years of their diagnosis, and 30% of those that do survive have severe side effects, including cognitive deficits, kidney failure, heart failure, and secondary cancers caused from the traditional toxic treatments.\u00a0\u00a0Because of the high level of toxicity associated with many current treatments and the plateau in survivorship rates, future success is dependent upon the development of new therapeutic approaches.<\/em><\/strong><\/p>\n<p><strong><em>Newly emerging adult cancer therapy is focused on drugs that kill only the cancer, and are not toxic to the normal cells of the patient. They accomplish this by using molecular genetic approaches to identify the \u2018Achilles heel\u2019 of each specific tumor type, then attacking this weak spot in a highly specific manner. This \u201ctargeted therapeutics\u201d has had great success in a number of adult cancers. Unfortunately, pediatric cancers are so different from adult cancers that targeted therapeutics must be developed specifically for pediatric cancer. It is imperative that research initiatives take place for childhood cancer that utilizes and integrates the latest molecular techniques for pediatric cancers, including: comparative genomic hybridization, large-scale re-sequencing of key oncogenes, proteomic profiling (particularly signaling pathways; phosphoproteomic profiling), and mRNA profiling.<\/em><\/strong><\/p>\n<p><strong><em>The identification of such therapeutic targets is essential to the future progress in identifying more effective therapies for children with cancer. Specifically, \u201ctarget identification\u201d is the first step in the high throughput drug screening pipeline (HTS), enabling subsequent assay development, high throughput screening, drug development, and pre-clinical and clinical studies. Through the development of molecularly targeted drugs for children with cancer, children world-wide could benefit from cancer therapies that would require minimal supportive care in contrast to today\u2019s toxic therapy. Children would benefit from additional drugs leading to a greater number of cures, and cures that would not be associated with life-long severe medical late-effects currently caused by standard cancer treatments.<\/em><\/strong><\/p>\n<p>&nbsp;<\/p>\n<div><\/div>\n<p><strong><em>1\u00a0International Agency for Research on Cancer, Globocan, 2002<\/em><\/strong><\/p>\n<p><strong><em>2\u00a0Global Action Against Cancer (\u00a0Geneva\u00a0: UICC\/WHO, updated edition 2005)<\/em><\/strong><\/p>\n<p><strong><em>3\u00a0Ries, L. A. G., Eisner, M. P., Kosary, C. L., Hankey, B. F., Miller, B. A., Clegg, L., Mariotto, A., Feuer, E. J., and Edwards, B. K. SEER Cancer Statistics Review, 1975-2002. 2005. National Cancer Institute.\u00a0Bethesda\u00a0,\u00a0MD.<\/em><\/strong><\/p>\n<p><strong><em>\u00a0<\/em><\/strong><\/p>\n<\/div>\n<div><\/div>\n<div><\/div>\n<\/div>\n<div><\/div>\n<\/div>\n<div>\n<div>\n<div>\n<p><a href=\"http:\/\/acco.org\/terms.aspx\" target=\"\" rel=\"\"><strong><em>Terms Of Use<\/em><\/strong><\/a><strong><em>\u00a0|\u00a0<\/em><\/strong><a href=\"http:\/\/acco.org\/privacy.aspx\" target=\"\" rel=\"\"><strong><em>Privacy Statement<\/em><\/strong><\/a><strong><em>\u00a0|\u00a0<\/em><\/strong><a target=\"\" rel=\"\"><strong><em>CLIENT LOGIN<\/em><\/strong><\/a><strong><em>\u00a0| |\u00a0<\/em><\/strong><a href=\"http:\/\/acco.org\/AboutUs\/ContactUs.aspx\" target=\"\" rel=\"\"><strong><em>Contact<\/em><\/strong><\/a><br \/>\n<strong><em>Copyright 2000-2013 by American Childhood Cancer Organization<\/em><\/strong><\/p>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n","protected":false},"excerpt":{"rendered":"<p>Posted on March 4, 2014 by sandrabeck Dear Friends, Rebekah Sizemore\u2019s son Naithan recently lost his Earthly life to DIPG, Diffuse Intrinsic Pontine Glioma, which is one of the deadliest pediatric cancers with virtually no survivors. \u00a0In tribute to Naithan in his birthday month, she is researching statistics for pediatric\u2026<\/p>\n<p class=\"continue-reading-button\"> <a class=\"continue-reading-link\" href=\"https:\/\/jacksangelsfoundation.com\/?p=1894\">Continue reading<i class=\"crycon-right-dir\"><\/i><\/a><\/p>\n","protected":false},"author":1,"featured_media":1831,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[1],"tags":[],"class_list":["post-1894","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-uncategorized"],"_links":{"self":[{"href":"https:\/\/jacksangelsfoundation.com\/index.php?rest_route=\/wp\/v2\/posts\/1894","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/jacksangelsfoundation.com\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/jacksangelsfoundation.com\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/jacksangelsfoundation.com\/index.php?rest_route=\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/jacksangelsfoundation.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=1894"}],"version-history":[{"count":0,"href":"https:\/\/jacksangelsfoundation.com\/index.php?rest_route=\/wp\/v2\/posts\/1894\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/jacksangelsfoundation.com\/index.php?rest_route=\/wp\/v2\/media\/1831"}],"wp:attachment":[{"href":"https:\/\/jacksangelsfoundation.com\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=1894"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/jacksangelsfoundation.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=1894"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/jacksangelsfoundation.com\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=1894"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}